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Scientist - Computational Biology (JP8346)

South San Francisco, Ca · Biotech/Pharmaceutical
Job Title: Scientist - Computational Biology (JP8346)
Location: South San Francisco California (remote until Covid-19 restrictions are lifted)
Employment Type: Contract
Business Unit: Clinical Biomarkers - Oncology 
Duration: 12 months with likely extensions
Job posting date: 4/16/2021
 
3 Key Consulting is hiring a Scientist - Computational Biology for a consulting engagement with our client, a leading global bio-pharmaceutical company.
 
Ideal candidate / Must have skills:
  • Experience must be within Pharma or Biotech and just academic
  • Drug development experience
  • Support the development of clinical biomarkers supporting company programs through the formulation and execution of biomarker data analysis
  • Perform assessment of biochemical coverage, patient stratification, indication selection in early and late clinical development programs and discovery of clinical insights at asset and portfolio levels through the application of knowledge discovery and data mining techniques
  • Develop translational informatics analysis workflows in a high-content, multi-omics, multi-modal data domain encompassing genomics, transcriptomics, proteomics, metabolomics and epigenomics domains
 

Job Summary:
The Clinical Biomarkers & Diagnostics (CBD) department is looking for a highly motivated Computational Biologist with expertise in clinical bioinformatics, biomarker development, assay development, ML algorithms & data science, statistical modeling, handling clinical data sets and a background in biology and computational sciences. This is a high-visibility, individual contributor role preferring experience within matrix environments representing the function and requiring the development of methods to support the entirety of the clinical portfolio. 


Responsibilities:
  • Support the development of clinical biomarkers supporting company programs through the formulation and execution of biomarker data analysis
  • Perform assessment of biochemical coverage, patient stratification, indication selection in early and late clinical development programs and discovery of clinical insights at asset and portfolio levels through the application of knowledge discovery and data mining techniques
  • Develop translational informatics analysis methods to enable the analysis of NGS data/Epigenomics assays/single-cell assays from clinical trials
  • Develop translational informatics analysis workflows in a high-content, multi-omics, multi-modal data domain encompassing genomics, transcriptomics, proteomics, metabolomics and epigenomics domains
  • Develop innovative best-practices for the next generation of clinical bioinformatics, such as the utilization of ctDNA-derived tumor burden as a prognostic biomarker/surrogate end point
  • Work with biologists, especially in immuno-oncology, to leverage information on targeted biological pathways along with development of computational algorithms to manage and mine internal and external genomics and other high-content databases
  • Provide leadership and expertise to the function in the areas of algorithm development, bioinformatics, data integration & management, visualization, analysis and presentation
  • May represent the clinical biomarkers & diagnostics team in company  program/portfolio teams as a biomarker analysis lead
  • Interface cross-functionally with the early development teams, assay laboratories, in-vitro diagnostics and biomarker representatives
Preferred Qualifications:
  • PhD in Bioinformatics, Mathematics, Statistics, Computer Science, Biology
  • A working knowledge of bioinformatics, applied mathematics and/or statistics to analyze multi-modal, multi-dimensional and large-scale biological data sets such as those from GWAS, next-generation sequencing, RNASeq and proteomics assays
  • A working knowledge of platforms and readouts utilized for the assessment of clinical biomarkers including flow cytometry, IHC, NGS, immunoassays, imaging and transcriptional profiling assays
  • Ability to translate biological and medical questions into analytical models providing actionable results
  • Programming experience in Python & R
  • Experience in implementing program-based strategies for both pharmacodynamic and patient stratification biomarkers
  • Familiarity with assay development and qualification requirements for clinical trial support
  • Ability to work in a highly matrixed environment and drive scientific and technical innovation collaboratively with other members of the group, as well as with the research community
  • Three or more years of relevant experience in the biotech or pharmaceutical industry
  • A strong scientific background with training in genetics and a proven track record of productivity
  • Strong written and oral communication skills, self-motivation, independence and leadership 
Employee Value Proposition:
Opportunity to be part of a science driven, data driven, open collaborative environment. Exposure to diverse and cross functional team. Will work with multiple therapeutic areas.
 
Red Flags
Lack of must have skills listed, lack of pharma or biotech experience, jumpy job history
 
Interview Process:
video
 
We invite qualified candidates to send your resume to resumes@3keyconsulting.com. If you decide that you’re not interested in pursuing this position, please feel free to look at other positions on our website www.3keyconsulting.com. You are welcome to also share this posting with anyone you think might be interested in applying for this role.

 
 
Regards,
 
3KC Talent Acquisition Team
 
 
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